100X University

How The Brain,
Body & Hormones
Actually Work

Every lesson organized by genre. Mechanism first, every claim cited, nothing invented. New to this? Start with the Start Here foundations page before anything else.

Recovery

Sleep, waste clearance, and system restoration
Sleep & Cognitive Function Glymphatic clearance, memory consolidation, REM emotional regulation, and what cutting sleep actually costs. D2 Receptor Recovery Getting the dopamine system back after chronic stimulant use, mechanism by mechanism.
Cold Exposure & The Brain Coming soon.

Neurotransmitters

The signaling molecules behind every cognitive function
Dopamine The inverted-U relationship between prefrontal dopamine and working memory. Norepinephrine The alpha-2A vs alpha-1 receptor split, and why stress hijacks focus. Acetylcholine Attention, memory, REM sleep, and the real racetam evidence. GABA Inhibitory tone, benzodiazepine tolerance, and the blood-brain-barrier question. Serotonin / SSRIs 5-HT receptor subtypes and how SSRIs actually work. Orexin / Wakefulness The lateral hypothalamic system behind modafinil and narcolepsy.

Growth Factors

The proteins that drive neuroplasticity
BDNF The most studied neurotrophin in cognitive performance research. NGF The original neurotrophin, the cholinergic link, and the real Lion's Mane mechanism. IGF-1 The growth factor that crosses the blood-brain barrier, and its cancer-risk tradeoff.

Longevity & Endocrinology

Aging, hormones, and the tradeoffs underneath both
Longevity & The Disposable Soma Theory Why organisms age, plus the eunuch and bodybuilder data. Testosterone, DHT & Estrogen The real neurochemistry, and why testosterone's mood effect runs through estrogen. Cortisol The HPA axis, dysregulation in both directions, and the epigenetics of early stress. Hair Loss & DHT The DHT mechanism, finasteride vs dutasteride, and topical alternatives. Non-Negotiables: PDE5 Inhibition The mechanism, the dementia-risk contradiction, and nutrient partitioning.

Pharmacology

How drugs interact with the brain's systems
SSRIs & SNRIs Mechanism, the delay, and the "chemical imbalance" oversimplification. Amphetamines & Methylphenidate Reverse transport vs reuptake inhibition, and the tolerance question. Modafinil & Caffeine Wakefulness without the same abuse liability, and why caffeine "gives you energy." The Racetam Family Piracetam through phenylpiracetam, compared against what's actually established.

Lifestyle Inputs

What you do every day shapes your neurobiology
Exercise & Neuroplasticity Which training variables actually move BDNF, and where the research disagrees. Natural Testosterone Optimization Sleep, resistance training, and body fat, the short list that's actually evidence-backed.
New here? Start with the foundations page →
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